Associate Professor
Associate Professor and Department Director
Shunsuke TERASAKA MD, PhD
Dr. Terasaka is considered a leading figure in the field of neurosurgery in the treatment of skull base tumor and complex brain stem lesions. He currently serves as a department director of the Hokkaido University Hospital.
After completing his residency in neurosurgery at Hokkaido Univeristy Hospital, he moved to the University of Arkansas for Medical Science as a clinical and research fellow under professor Al-Mefty and professor G. Yasargil. Then he worked as a clinical fellow under professor T. Fukuhsima in Allegheny General Hospital for skull base training in 1996. In 2006, he was appointed assistant professor of the Hokkaido Univeristy and seven years later became associate professor of neurosurgery. He has served as a department director since 2016. Throughout his career, he has focused his attention on the skull base surgery. His main research interests have included surgical anatomy, and development of surgical devices and materials. Dr. Terasaka has published over 150 peer-reviewed papers in various journals.
He is currently putting large amount of his effort into international collaboration as he believes communication about medical education, research and care throughout the world will upgrade our medical skills.
Profile:
1995 Clinical & research fellow at University of Arkansas for Medical Science (USA)
1996 Clinical & research fellow at Allegheny General Hospital (USA)
2004 Chief of Neurosurgery, Teine Keijinkai Medical Center
2006 Assistant professor of Hokkaido Univesity
2013 Associate professor of Hokkaido University
2016 Department director of Hokkaido University
Selected Professional Memberships and Appointments
Executive board member of Japanese Neurosurgical Society
Executive board member of Japanese Society for Skull Base Surgery
Executive board member of Japanese Congress for Brain Tumor Surgery
Internationnal fellow of Americal Association of Neurological Surgeons
Selected Publications
1. Terasaka S, Taoka T, Kuroda S, et al.: Efficacy and safety of non-suture durak closure using a novel dural substitute consisting of polyglycolic acid felt and fibrin glue to prevent cerebrospinal fluid leakage -A non-controlled, open label, multicenter clinical trial-. J Mater Sci: Mater Med 28: 69, 2017
2. Terasaka S, Asaoka K, Yamaguchi S, et al.: A significant correlation between delayed cure after microvascular decompression and positive response to preoperative anticonvulsant therapy in patients with hemifacial spasm. Neurosurg Rev 39(4): 607-613, 2016
3. Yamaguchi S, Terasaka S, Kobayashi H, et al.: Prognostic Factors for Survival in Patients with High-Grade Meningioma and Recurrence-Risk Stratification for Application of Radiotherapy. PLoS One 12; 9(5): e97108, 2014
4. Asaoka K, Terasaka S: Combined petrosal approach for resection of petroclival meningioma. Neurosurg Focus 36 (Suppl 1): 1, 2014
5. Terasaka S, Asaoka K, Kobayashi H, et al.: Anterior interhemispheric approach for tuberculum sellae meningioma. Neurosurgery 68 (1 Suppl Operative): 84-88, 2011
Professor and Chairman
■ Curriculum vitae
1994- Department of Neurosurgery, Tohoku University
1997- Postdoctoral fellow, UCSF, Stanford University (Prof. Pak H. Chan)
2000 Ph.D. (Tohoku University Graduate School of Medicine)
2003- Assistant Professor, Department of Neurosurgery, Tohoku University
2011- Director, Department of Neurosurgery, Sendai Medical Center
2014- Associate Professor, Department of Neurosurgery, Tohoku University
2017- Director, Department of Neurosurgery, Kohnan Hospital, Sendai
2021- Professor and Chairman, Hokkaido University (Neurosurgery), Sapporo
■ Professional Affiliations etc.
The Japan Neurosurgical Society (Council Member, International Committee Member)
The Japanese Congress of Neurological Surgeons (Steering Committee Member, International Committee Chair)
Japanese Society of Surgery for Cerebral Stroke (Council Member, Editorial Board)
The Japan Stroke Society (Council Member, Guideline Committee)
Japanese Society of Cerebral Blood Flow and Metabolism (Secretary)
■ Academic Interests
Microsurgery for cerebrovascular diseases; Moyamoya disease, Aneurysm surgery, Molecular biology of cerebral ischemia, Cerebral blood flow and metabolism.
Associate Professor
Associate Professor
Naoki Nakayama MD, PhD
Dr. Nakayama ‘s clinical expertise is in the surgical treatment of complex intracranial vascular diseases including bypass-combined cerebral aneurysm treatment, surgical treatment of arteriovenous malformations, Moyamoya disease, and carotid endarterectory (1900 cases in the past 14 years). Dr. Nakayama comments, “It is our mission to provide the latest and finest level of surgery under the collaboration of various medical team and with advanced medical tools. The surgery must be built with meticulous attention and uncompromised professional theory. I owe this to myself and working to instruct the junior fellows in these habits.” Dr. Nakayama’s research interests include novel treatments for the enlargement and rupture mechanisms of cerebral aneurysms using computerized hemodynamics analysis and histological examinations.
Profile:
1995 Research fellow at University of California, Davis (USA)
1996 Research fellow at Brain Research Institute, Niigata University
2006 Assistant professor of Hokkaido Univesity
2013 Associated professor of Hokkaido University
Selected Professional Memberships and Appointments
Executive board member of Japanese Neurosurgical Society
Executive board member of Japanese Society on Surgery for Cerebral Stroke
Executive board member of Japan Stroke Society
Executive board member of Japanese Cerebral Blood Flow and Metabolism
Executive board member of Cardiovascular Stroke Society of Japan
Review board of Neurologia Medico-Chirurgica
Review board of Journal of Stroke & Cerebrovascular Disease
Selected Publications
1 Nakayama N, Kuroda S, Houkin K, Takikawa S, Abe H. Intraoperative measurement of arterial blood flow using a transit time flowmeter: Monitoring of hemodynamic changes during cerebrovascular surgery.Acta Neurochir (Wien) 143,17-24,2000
2 Single ellipsoid diffusion tensor analysis. pp. 227-232. (Nakada T (Ed.), Integrated Human Brain Science : Theory, Method Application (Music), Elsevier Science B.V.), 2000
Associate Professor
Associate Professor
Ken Kazumata, MD, PhD
Dr. Kazumata’s main clinical interests are the surgical treatment of cerebral vascular diseases. In particular, he studies cerebral aneurysms, arteriovenous malformation, and Moyamoya disease. He is also engaged in clinical research for treating subarachnoid hemorrhage.
Selected Professional Memberships and Appointments
Member of Japanese Neurosurgical Society
Member of Japanese Society on Surgery for Cerebral Stroke
Selected Publications
1.◯Kazumata K, Tha KK, Uchino H, Shiga T, Shichinohe H, Ito M, Nakayama N, Abumiya T. Topographic changes in cerebral blood flow and reduced white matter integrity in the first 2 weeks following revascularization surgery in adult moyamoya disease. J Neurosurg. 2016:1-10
2.◯Kazumata K, Tha KK, Narita H, Ito YM, Shichinohe H, Ito M, Uchino H, Abumiya T. Characteristics of diffusional kurtosis in chronic ischemia of adult moyamoya disease: Comparing diffusional kurtosis and diffusion tensor imaging. AJNR Am J Neuroradiol. 2016;37:1432-1439
3.◯Kazumata K, Tha KK, Narita H, Shichinohe H, Ito M, Uchino H, Abumiya T. Investigating brain network characteristics interrupted by covert white matter injury in patients with moyamoya disease: Insights from graph theoretical analysis. World Neurosurg. 2016;89:654-665 e652
4.◯Kazumata K, Tha KK, Narita H, Kusumi I, Shichinohe H, Ito M, Nakayama N, Houkin K. Chronic ischemia alters brain microstructural integrity and cognitive performance in adult moyamoya disease. Stroke. 2015;46:354-360
5.◯Kazumata K, Ito M, Tokairin K, Ito Y, Houkin K, Nakayama N, Kuroda S, Ishikawa T, Kamiyama H. The frequency of postoperative stroke in moyamoya disease following combined revascularization: A single-university series and systematic review. J Neurosurg. 2014;121:432-440
Associate Professor
Associate Professor
Hiroyuki Kobayashi MD, PhD
Dr. Kobayashi specializes in therapeutic approaches to brain tumors, particularly multidisciplinary approaches, neuronavigation, neuro-endoscopy, and intraoperative fluorescence diagnostics. He is one of the leaders in the field of Glioma and primary central nervous system lymphoma (PCNSL). Dr. Kobayashi emphasizes “Surgery is indeed one of the most important aspect of pediatric brain tumor, however, adjunctive therapies including chemotherapy, radiation therapy and even growth support are also mandatory treatment tools for sick children. I am one of the members of nationwide society (JCOG, JCCG) for providing better treatment for brain tumor patients.”
He currently pays his effort on the field of neuro-endoscopy starting its application from pituitary adenoma to skull base tumor resection. His basic research are focused on the novel treatment methods using photo- and sono-dynamics for brain tumor treatment which is thought to be the major future stream.
Selected Professional Memberships and Appointments
Member of Japanese Neurosurgical Society
Member of Japanese Neurosurgical Congress
Member of Japan Society for Neuro-Oncology
Member of Japanese Society for Neuroendoscopy
Member of Japanese Society for Hypothalamic and Pituitary Tumors
Member of Japanese Society for Skull Base Surgery
Member of the Japan Photodynamic Association
Selected Publications
・Kobayashi H, Katsuyuki Asaoka, Shunsuke Terasaka, Jun-ich Murata: Primary Closure of a Cerebrospinal Fluid Fistula by Nonpenetrating Titanium Clips in Endoscopic Endonasal Transsphenoidal Surgery: Technical Note. Skull Base. 2011 Jan; 21(1):47-52
・Kobayashi H, Kawabori M, Terasaka S, Murata J, Houkin K: A possible mechanism of isolated oculomotor nerve palsy by apoplexy of pituitary adenoma without cavernous sinus invasion: a report of two cases. Acta Neurochir (Wien). 2011 Dec;153(12):2453-6. Epub 2011 Sep 27.
・KOBAYASHI H, Kenji HIRATA, Shigeru YAMAGUCHI, Shunsuke TERASAKA, Tohru SHIGA, Kiyohiro HOUKIN: Usefulness of FMISO—PET for Glioma Analysis. Neurol Med Chir (Tokyo). 53(11):773-8. 2013
・Endo S, Kudo N, Yamaguchi S, Sumiyoshi K, Motegi H, Kobayashi H*, Terasaka S, Houkin K.: Porphyrin Derivatives-Mediated Sonodynamic Therapy for Malignant Gliomas In Vitro. Ultrasound Med Biol. 2015 Jun. 10
Associate Professor
Associate Professor
Shigeru Yamaguchi MD, PhD
Dr. Yamaguchi’s clinical expertise is the diagnosis, surgical treatment, and chemotherapy for malignant and benign brain tumors, he is especially putting his effort on the advanced clinical study using PET scan and biogenetics for malignant glioma. Dr. Yamaguchi states, “Amount of surgical resection has strong relation with patients` prognosis. I am trying to achieve maximum resection of the tumor with latest technology such as intra-operative navigation, and fluorescence diagnosis. As for basic research, Dr. Yamaguchi is putting his effort on the clarification of pathology for glioma, meningioma, and pediatric brain tumor using biogenetical approach. He is also trying to figure out the novel ligand for PET scan such as methionine and low oxygen imaging, and adopting aminolaevulinic acid for brain tumor diagnosis modality. It is his highest goal to achieve the bridge from the bench to bed.
Profile:
2011 Research fellow at Baylor College of Medicine (USA)
2014 Assistant professor of Hokkaido University (Dept. of Nuclear Medicine)
2016 Assistant professor of Hokkaido University (Dept. of Neurosurgery)
Selected Professional Memberships and Appointments
Member of Japanese Neurosurgical Society
Member of Japanese Neurosurgical Congress
Member of Japan Society for Neuro-Oncology
Member of Japanese Congress for Brain Tumor Surgery
Member of Japan Society of Brain Tumor Pathology
Selected Grants, Honors and Awards
2012 Grant: Computational Cancer Biology Training Program (Gulf Coast Consirtia, Texas, USA)
Selected Publications
・ Yamaguchi S, Hirata K, Toyonaga T, Kobayashi K, Ishi Y, Motegi H, Kobayashi H, Shiga T, Tamaki N, Terasaka S*, Houkin K: Change in 18F-Fluoromisonidazole PET is an Early Predictor of the Prognosis in the Patients with Recurrent High-grade Glioma Receiving Bevacizumab Treatment. PLoS One. 11(12): e0167917, 2016
・ Toyonaga T, Hirata K, Yamaguchi S*, Hatanaka KC, Yuzawa S, Manabe O, Kobayashi K, Watanabe S, Shiga T, Terasaka S, Kobayashi H, Kuge Y, Tamaki N: 18F-fluoromisonidazole positron emission tomography can predict pathological necrosis of brain tumours.Eur J Nucl Med Mol Imaging. 43(8): 1469-1476, 2016
・ Wang L, Yamaguchi S, Burstein MD, Terashima K, Chang K, Ng HK, Nakamura H, He Z, Doddapaneni H, Lewis L, Wang M, Suzuki T, Nishikawa R, Natsume A, Terasaka S, Dauser R, Whitehead W, Adekunle A, Sun J, Qiao Y, Marth G, Muzny DM, Gibbs RA, Leal SM, Wheeler DA, Lau CC*: Novel somatic and germline mutations in intracranial germ cell tumours. Nature. 511(7508), 241-245, 2014
・ Yamaguchi S, Terasaka S*, Kobayashi H, Asaoka K, Motegi H, Nishihara H, Kanno H, Onimaru R, Ito YM, Shirato H, Houkin K: Prognostic Factors for Survival in Patients with High-Grade Meningioma and Recurrence-risk Stratification for Application of Radiotherapy. PLoS One. 9(5), e97108, 2014
・ Yamaguchi S, Kobayashi H, Terasaka S*, Ishii N, Ikeda J, Kanno H, Nishihara H, Tanaka S, Houkin K: The Impact of Extent of Resection and Histological Subtype on the Outcome of Adult Patients with High-grade Gliomas. Jpn J Clin Oncol. 42(4), 270-277, 2012
Associate Professor
Associate Professor
Toshitaka Seki MD, PhD
Dr. Seki is an expert in treating spinal disorders, including spinal tumor, syringomyelia, spinal vascular malformation, and spondylosis. He also treats patients suffering intractable pain, involuntary movement, Parkinson disease, and spasm. With regard to his practice, Dr. Seki believes, “We have been treating and gathered diagnostic and therapeutic experience regarding spinal tumor, spinal arteriovenous malformation and syringomyeria. It is currently very difficult to completely resect spinal astrocytoma, so we are adopting novel method called “Radiation spinal cord transection” with the help of the department of radiology for selected patients and gaining longer survival period. We are also working multidisciplinary approach to the spinal intradural arteriovenous malformation, which is one of the most difficult cases in the group of arteriovenous malformations. We believe that there are the only university that currently has this type unique of collaboration of neurosurgery and neuroradiology in Japan.”
Selected Professional Memberships and Appointments
Member of Japanese Neurosurgical Society
Member of Japanese Neurosurgical Congress
Member of Neurospinal Society of Japan
Member of Japanese Society for Spine Surgery and Related Research
Member of Japan Medical Society of Spinal Cord Lesion
Member of Japan Epilepsy Society
Member of the Japan Society for Stereotactic and Functional Neurosurgery
Member of American Association of Neurological Surgeons
Member of the Congress of Neurological Surgeons
Selected Grants, Honors and Awards
2003 Takakuwa Eimatsu Scholarship (Honor program of the Hokkaido University)
2004 Tsuru Award
2006 Mayfield Research Award(22nd AANS Annual Meeting)
Selected Publications
Seki T, Hida K, Yano S, Aoyama T, Koyanagi I, Sasamori T, Hamaguchi S, Houkin K. Clinical Factors for Prognosis and Treatment Guidance of Spinal Cord Astrocytoma. Asian Spine J 10:748-754, 2016
Seki T, Hida K, Yano S, Aoyama T, Koyanagi I, Houkin K. Surgical Outcomes of High-Grade Spinal Cord Gliomas. Asian Spine J 9:935-941, 2015
Seki T, Hida K, Yano S, Sasamori T, Hamaguchi S, Koyanagi I, Houkin K. Surgical Outcome of Children and Adolescents with Tethered Cord Syndrome. Asian Spine J 10:940-944, 2016
Seki T, Fehlings MG. Mechanistic insights into posttraumatic syringomyelia based on a novel in vivo animal model. Laboratory investigation. J Neurosurg Spine. 8:365-375, 2008
Seki T, Hida K, Tada M, Koyanagi I, Iwasaki Y. Role of the bcl-2 gene after contusive spinal cord injury in mice. Neurosurgery 53:192-198, 2003
Seki T, Hida K, Tada M, Koyanagi I, Iwasaki Y. Graded contusion model of the mouse spinal cord using a pneumatic impact device. Neurosurgery 50:1075-1082, 2002
Associate Professor
Associate Professor
Takeo Abumiya MD, PhD
Dr. Abumiya’s clinical expertise is the medical management of cerebral stroke. His work covers wide range of neurovascular diseases, ranging from the thrombolytic therapy at the acute stage to antithrombotic treatment and risk factor management at the chronic stages. Dr. Abumiya states, “I always try to provide optimal treatment based on the patient clinical condition as well as their personal situation. I take this in mind that bringing patient to understand their illness and to participate in the treatment by themselves are one of the main forces to achieve good health.
As for basic research, he spent the early years of his career as a neuroscientist at the Japan National Cardiovascular Research Center, working on breakthrough studies in the field of thrombosis and hemostasis, and currently trying to figure out the mechanisms of ischemic reperfusion injury, brain protection in the acute stage, and cellular function at the ischemic status. As for the clinical research field, Dr. Abumiya is focusing to clarify the pathophysiology of the cerebrovascular disease from blood flow hemodynamic, using modern technology such as 4-dementional MR angiography and Electromagnetic Spinning Sphere Viscometer. He is now also trying to establish new therapeutic methods against ischemic reperfusion injury and conducting a clinical trial using brain hypothermia for acute ischemic stroke (COOL IVR Study).
Profile:
1991 Research fellow at Japan National Cardiovascular Research Center
1996 Research fellow at The Scripps Research Institute (USA)
2013 Assistant professor of Hokkaido Univesity
2016 Associated professor of Hokkaido University
Selected Professional Memberships and Appointments
Executive board member of Japan Stroke Society
Member of Japanese Neurosurgical Society
Member of Japanese Society on Surgery for Cerebral Stroke
Member of Japanese Cerebral Blood Flow and Metabolism
Member of Japanese Society on Thrombosis and hemostasis
Member of the Japanese Vascular Biology and Medicine Organization
Selected Publications
1, Kurisu K, Abumiya T, Ito M, Gekka M, Osanai T, Shichinohe H, Nakayama N, Kazumata K, Houkin K. Transarterial regional hypothermia provides robust neuroprotection in a rat model of permanent middle cerebral artery occlusion with transient collateral hypoperfusion. Brain Res. 1651:95-103. 2016
2, Furukawa K, Abumiya T, Sakai K, Hirano M, Osanai T, Shichinohe H, Nakayama N, Kazumata K, Hida K, Houkin K. Increased Blood Viscosity in Ischemic Stroke Patients with Small Artery Occlusion Measured by an Electromagnetic Spinning Sphere Viscometer. J Stroke Cerebrovasc Dis. S1052-3057. 2016.
3, Furukawa K, Abumiya T, Sakai K, Hirano M, Osanai T, Shichinohe H, Nakayama N, Kazumata K, Aida T, Houkin K. Measurement of human blood viscosity by an electromagnetic spinning sphere viscometer J Med Eng Technol. 40(6):285-92. 2016
4, Kurisu K, Abumiya T, Nakamura H, Shimbo D, Shichinohe H, Nakayama N, Kazumata K, Shimizu H, Houkin K. Transarterial Regional Brain Hypothermia Inhibits Acute Aquaporin-4 Surge and Sequential Microvascular Events in Ischemia/Reperfusion Injury. Neurosurgery. 79(1):125-34. 2016
5, Shimbo D, Abumiya T, Shichinohe H, Nakayama N, Kazumata K, Houkin K. Post-ischemic intra-arterial infusion of liposome-encapsulated hemoglobin can reduce ischemia reperfusion injury. Brain Res.1554 59-66.2014
6, Abumiya T, Katoh M, Moriwaki T, Yoshino M, Aoki T, Imamura H, Aida T, Scichinohe H, Nakayama N, Kazumata K, Houkin K. Utility of early post-treatment single-photon emission computed tomography imaging to predict outcome in stroke patients treated with intravenous tissue plasminogen activator. J Stroke Cerebrovasc Dis. 23(5):896-901. 2014
7, Abumiya T, Katoh M, Moriwaki T, Yoshino M, Aoki T, Imamura H, Aida T, Nakayama N, Houkin K. Small but severe residual hypoperfusion relates to symptomatic hemorrhage even after early perfusion improvement in tissue plasminogen activator therapy. Cerebrovasc Dis. 34(5-6):446-7. 2012
Assistant Professor
Assistant Professor
Toshiya Osanai MD, PhD
Dr. Osanai is a neurosurgeon specializing in neuro-endovascular surgery and is one of the few doctors who achieved supervisory qualification for endovascular surgery. Endovascular treatment deals with catheter and is considered to be one of the most non-invasive treatments nowadays. Dr. Osanai emphasizes “The development of devices and technologies in this field is astonishing. Endovascular treatments in the field of cerebrovascular diseases have shown significant benefit to the patients and proven its usefulness in many trials. We are probably standing on the edge of new era where endovascular treatments are heading to the main treatment modality for most of the cerebrovascular disease.” Dr. Osanai has also been putting his effort on the arteriovenous shunt disease such as arteriovenous malformation, high blood flow brain tumor, and spinal arteriovenous shunt disease. These diseases require multidisciplinary approach by different specialist and neuro-endovascular surgeon can be the key player for treatment.
As for research, Dr. Osanai is engaged in the development of new endovascular devices, modeling remote medical care, and analyzing the system of lesion-wide emergency endovascular support system.
Selected Professional Memberships and Appointments
Member of Japanese Neurosurgical Society
Member of Japan Stroke Society
Member of Japanese Society on Surgery for Cerebral Stroke
Member of Japanese Cerebral Blood Flow and Metabolism
Member of Japanese Society for Neuroendovascular Therapy
Selected Publications
1: Osanai T, Pasupuleti V, Deshpande A, Thota P, Roman Y, Hernandez AV, Uchino K. Acute endovascular reperfusion therapy in ischemic stroke: a systematic review and meta-analysis of randomized controlled trials. PLoS One. 2015 Apr 27;10(4):e0122806.
2: Osanai T, Bain M, Hui FK. Versatile fill coils: initial experience as framing coils for oblong aneurysms. A technical case report. Interv Neuroradiol. 2014 May-Jun;20(3):287-94.
3: Osanai T, Bain MD, Toth G, Hussain MS, Hui FK. Balloon-augmented Onyx endovascular ligation: initial human experience and comparison with coil ligation. J Neurointerv Surg. 2014 May 26.
4: Fujima N, Osanai T, Shimizu Y, Yoshida A, Harada T, Nakayama N, Kudo K, Houkin K, Shirato H. Utility of noncontrast-enhanced time-resolved four-dimensional MR angiography with a vessel-selective technique for intracranial arteriovenous malformations. J Magn Reson Imaging. 2016 Oct;44(4):834-45
5: Shimoda Y, Osanai T, Nakayama N, Ushikoshi S, Hokari M, Shichinohe H, Abumiya T, Kazumata K, Houkin K. De novo arteriovenous malformation in a patient with hereditary hemorrhagic telangiectasia. J Neurosurg Pediatr. 2016 Mar;17(3):330-5
Assistant Professor
Dr. Sugiyama ‘s clinical expertise is in the surgical treatment of complex intracranial vascular diseases including cerebral aneurysms, arteriovenous malformations, moyamoya disease, and occlusive cerebrovascular diseases. He has published several books on microneurosurgical techniques, with his current academic interests spanning surgical data science with advanced engineering technologies, virtual reality in surgical simulation, surgical education, and pathological mechanisms of cerebrovascular diseases.
Profile
2010 The head physician, Department of Neurosurgery, Teine Keijinkai Hospital, Sapporo, Japan
2015 The research fellow, Project neuroArm, Department of Clinical Neuroscience and Hotchkiss Brain Institute, University of Calgary
2018 Assistant Professor, Department of Neurosurgery, Hokkaido University Hospital
Selected Professional Memberships and Appointments
Member of Japanese Neurosurgical Society
Member of Japanese Society on Surgery for Cerebral Stroke
Member of Japan Stroke Society
Selected Publications
1) Sugiyama T, Lama S, Gan LS, Maddahi Y, Zareinia K, Sutherland GR; Forces of Tool-tissue Interaction to Assess Surgical Skill Level; JAMA Surgery 153(3): 234-242, 2018.
2) Sugiyama T; Mastering Intracranial Microvascular Anastomoses -Basic Techniques and Surgical Pearls, Medicus Shuppan, 2017
3) Sugiyama T, Nakamura T, Ito Y, Tokairin K, Kazumata K, Nakayama N, Houkin K; A pilot study on measuring tissue motion during carotid surgery using video-based analyses for the objective assessment of surgical performance; World Journal of Surgery (In press)
4) Sugiyama T, Kazumata K, Asaoka K, Osanai T, Shimbo D, Uchida K, Yokoyama Y, Nakayama N, Itamoto K, Houkin K; Reappraisal of microsurgical revascularization for anterior circulation ischemia in patients with progressive stroke; World Neurosurgery 84(6): 1579-1588, 2015
5) Sugiyama T, Kuroda S, Osanai T, Shichinohe H, Kuge Y, Ito M, Kawabori M, Iwasaki Y; Near-infrared fluorescence labeling allows non-invasive tracking of bone marrow stromal cells transplanted into rat infarct brain; Neurosurgery 68(4): 1136-1047, 2011
助教 (客員)
■診療グループ
脊髄・機能外科班
■専門・研究テーマ
脊髄外科および機能外科分野を担当しています.機能外科では,脳深部刺激療法(DBS),脊髄刺激療法(SCS),バクロフェン持続髄注療法(ITB療法)を行っています.また,難治性てんかんに対する迷走神経衝撃療法(VNS)も行っています.さらに,外来診療では,脳卒中後の片麻痺患者さんを中心に,ボツリヌス療法を行っています.研究では,ラット脊髄損傷モデルを用いてSCSの有効性を評価しています.
■略歴
2006年 網走脳神経外科リハビリテーション病院
2007年 釧路労災病院 脳神経外科
2008年 北海道大学病院 脳神経外科
2009年 小樽市立医療センター 脳神経外科
2011年 日本大学医学部脳神経外科
2011年 札幌麻生脳神経外科病院
2013年 北海道大学神経内科 医員
2014年 北海道大学脳神経外科 医員
2015年 北海道大学脳神経外科 特任助教
2016年 北海道大学脳神経外科 助教
■所属学会
日本脳神経外科学会,日本脳神経外科コングレス,日本定位・機能神経外科学会,日本ニューロモデュレーション学会,日本脊髄外科学会,日本脊髄障害医学会,日本てんかん学会,日本臨床神経生理学会,日本脳卒中学会
■業績
・代表論文
Sasamori T, Hida K, Osanai T, Yano S, Seki T, Houkin K. Health-rekated quality of life in patients with spinal dural arteriovenous fistulae. Neurosurg Rev, 2016 [Epub ahead of print]
Sasamori T, Hida K, Yano S, Asano T, Seki T, Houkin K. Long-term outcomes after surgical and endovascular treatment of spinal dural arteriovenous fistulae. Eur Spine J 25(3):748-54, 2016
Sasamori T, Hida K, Osanai T, Yano S, Seki T, Houkin K. A Survey of Chronic Pain Due to Spinal Dural Arteriovenous Fistulae. Neurosurgery 77(1):113-8, 2015
・学会発表
Sasamori T, Hida K, Osanai T, Yano S, Seki T, Houkin K: Health-rekated quality of life in patients with spinal dural arteriovenous fistulae, 10th Asia Pacific Cervical Spine Society Meeting, Seoul, 2016
Sasamori T, Hida K, Osanai T, Yano S, Seki T, Chiba Y, Houkin K: Chronic pain due to spinal dural arteriovenous fistulae during follow-up, EANS Annual Meeting, Madrid, 2015
Sasamori T, Yano S, Hida K, Chiba Y, Morimoto D, Seki T, Isu T, Saito H, Houkin K: Efficacy of spinal cord stimulation for neuropathic pain due to spinal cord lesions, 82nd AANS Annual Scientific Meeting, San Francisco, 2014
等
Assistant Professor
Assistant Professor
Hiroaki Motegi MD, PhD
Dr. Motegi specializes in skull base surgery for difficult meningioma and schwannoma, and neuro-endoscopy for pituitary adenoma. Diagnosis and treatment of malignant tumors such as glioma are also his important therapeutic field. Dr. Motegi states “it is quite important to have the maximum resection for these kinds of malignant tumor with lowest complication rate. I pay full attention not only to perform standard treatment methods, but also to search for better treatment technique for the patients”. He is also the chief faculty engaged in medical student educational program. He is running many courses such as bypass surgery off-the-job training and try to provide latest knowledge to med-student.
Selected Professional Memberships and Appointments
Member of Japanese Neurosurgical Society
Member of Japan Society for Neuro-Oncology
Member of Japanese Congress for Brain Tumor Surgery
Member of Japanese Society for Skull Base Surgery
Member of Japanese Society for Neuroendoscopy
Member of the Japanese Society for Pediatric Neurosurgery
Selected Publications
Motegi H, M.D. Kobayashi H, M.D. Terasaka S, M.D. Yamaguchi S, M.D. Ishi Y, M.D. Ito Y, M.D. Houkin K, M.D. Application of endoscopic ultrasonography to intraventricular lesions Acta Neurochir. Jan 2016
Motegi H, Kamoshima Y, Terasaka S, Kobayashi H, Houkin K.. Type 1 collagen as a potential niche component for CD133-positive glioblastoma cells. Neuropathology. 2014 Aug;34(4):378-85.
Motegi H, Kamoshima Y, Terasaka S, Kobayashi H, Yamaguchi S, Tanino M, Murata J, Houkin K. IDH1 mutation as a potential novel biomarker for distinguishing pseudoprogression from true progression in patients with glioblastoma treated with temozolomide and radiotherapy. Brain Tumor Pathol. 2013 Apr;30(2):67-72.
Motegi H, Isobe M, Isu T, Kamiyama H. A surgical case of delayed coil migration after balloon-assisted embolization of an intracranial broad-neck aneurysm: case report. Neurosurgery. 2010 Dec;67(2 Suppl Operative):516-21.
Motegi H, Kobayashi H, Terasaka S, Ishii N, Ito M, Shimbo D, Kubota K, Houkin K.
Hemorrhagic onset of rhabdoid meningioma after initiating treatment for infertility.
Brain Tumor Pathol. 2012 Oct;29(4):240-4.
Hokkaido University Chairperson
Professor, Hospital Director, and University Vice President
Kiyohiro Houkin MD, PhD
Dr. Houkin is an expert in surgical treatment of cerebrovascular disease, such as cerebral aneurysm, and Moyamoya disease. He also serves as a director of Hokkaido University hospital which requires broad experience and responsibility throughout all medical fields and led him to one of the top leaders in the field of risk and emergency medical management in Japan. As a neuroscientist, he has been engaged in basic research regarding Moyamoya disease and stem cell therapy for ischemic stroke. He has been appointed to many important executive board member as listed below.
Profile:
2000 Associate Professor at Hokkaido University Department of Neurosurgery
2001 Professor and Chairman at Sapporo Medical University Department of Neurosurgery
2010 Professor and Chairman at Hokkaido University Department of Neurosurgery
Vice-director of Hokkaido University Hospital
2013 Director of Hokkaido University Hospital
2017 Vice president of Hokkaido University
Selected Professional Memberships and Appointments
Executive board member of Japanese Neurosurgical Society
Executive board member of Japanese Cerebral Blood Flow and Metabolism
Executive board member of Japanese Society on Surgery for Cerebral Stroke
Executive board member of Japan Stroke Society
Member of American Academy of Neurological Surgery
Member of Science Council of Japan
Selected Grants, Honors and Awards
1995 Kanae Foundation Research grants
1998 Suzuki Award by Japanese Society on Surgery for Cerebral Stroke
1999 Hokkaido Medical Association Award, Hokkaido Prefectural governor Award
2011 Miraha Award by Mihara Cerebrovascular disorder research promotion fund
Selected organized meetings
2011 The 6th International Mt Bandai Symposium on Neuroscience
2011 The 40th annual meeting of Japanese Society on Surgery for Cerebral Stroke
2013 The 3rd International Moyamoya Meeting
2013 The 13th annual meeting of the Japanese Society of Molecular Neurosurgery
2013 The 25th annual meeting of the Japanese Society of Cerebral Blood Flow and Metabolism
2015 The 74th annual meeting of the Japan Neurosurgical Society
2016 The 41th annual meeting of the Japan Stroke Society
Specially Appointed Associate Professor, Department of Neuronal Cell Therapy
Associate Professor
Masahito Kawabori MD, PhD
Dr. Kawabori ‘s clinical expertise is in the surgical treatment of cerebrovascular disease in both open surgery and endovascular surgery. He is one of the qualified surgeons for endovascular thrombectomy and does his practice not only in University hospital but also in the affiliated hospitals. He is the principal investigator for the stem cell clinical trial named “Research on Advanced Intervention using Novel Bone Marrow Stem cell (RAINBOW) project”, and stem cell therapy for traumatic brain injury. Dr. Kawabori’s research interests include stem cell therapy for brain damage, mechanisms of sphingolipid for protecting brain from various damage. He pays his effort on the education of younger neurosurgeons about cerebrovascular disease and endovascular treatment.
Profile:
2011 Research fellow at University of California, San Francisco (USA)
2016 Assistant professor of Hokkaido University
Selected Professional Memberships and Appointments
Member of Japanese Neurosurgical Society
Member of Japanese Society on Surgery for Cerebral Stroke
Member of Japan Stroke Society
Member of Japanese Society for Neuroendovascular Therapy
Selected Publications
・Kawabori M, et al. Triggering receptor expressed on myeloid cells 2 (TREM2) deficiency attenuates phagocytic activities of microglia and exacerbates ischemic damage in experimental stroke. J Neurosci. 2015;35(8):3384-96
・Kawabori M, et al. Inflammatory responses in brain ischemia. Curr Med Chem. 2015;22(10):1258-77. Review.
・Kawabori M, et al. The role of the microglia in acute CNS injury. Metab Brain Dis. 2015;30(2):381-92.
・Kawabori M, et al. Effective surgical revascularization improves cerebral hemodynamics and resolves headache in pediatric Moyamoya disease. World Neurosurg. 2013 Nov;80(5):612-9
・Kawabori M, et al. Intracerebral, but not intravenous, transplantation of bone marrow stromal cells enhances functional recovery in rat cerebral infarct: an optical imaging study. Neuropathology. 2012 32(3):217-26
Selected Grants, Honors and Awards
2011 President`s Award for Japan Neurosurgical International Forum
2011 Ken’s Award for JNEF
2011 Best Article of the Year for Hokkaido Medical Society
2012 Research grant of Hakuju-kai Medical Society
2013 Oversea Research fellowship of Uehara Memorial Foundation
2015 Furate Award for Hokkaido University Graduate School of Medicine
2016 Takakuwa Eimatsu Scholarship (Honor program of the Hokkaido University)
Kita 15, Nishi 7, Kita-ku, Sapporo, Hokkaido
TEL:011-716-1161 FAX:011-708-7737